2020 San Antonio Breast Cancer VIRTUAL Symposium (SABCS)
(December 8-11th)
TBCRC 044: Randomized phase II study of pembrolizumab and carboplatin versus carboplatin alone for chest wall recurrence of breast cancer
Neelima Vidula, Rita Nanda, Kathy Miller, Paula Pohlmann, Vandana Abramson, Leisha Emens, Ben Park, Minetta Liu, Andrei Goga, and Hope S. Rugo
Abstract: #OT-13-09
Ongoing Trials Posters: Wednesday, December 9th: 8am CT
Randomized Phase II Trial to Evaluate Alisertib Alone or Combined with Fulvestrant for Advanced, Endocrine-resistant Breast Cancer (TBCRC 041)
Tufia C Haddad, Antonino B D’Assoro, Vera J Suman, Jodi M Carter, Brendan P McMenomy, Erica L Mayer, Meghan S Karuturi, Aki Morikawa, P Kelly Marcom, Claudine J Isaacs, Sun Young Oh, Amy S Clark, Ingrid A Mayer, Khandan Keyomarsi, Roberto A Leon-Ferre, Karthik V Giridhar, Ciara C O’Sullivan, Prema P Peethambaram, Timothy J Hobday, Minetta C Liu, James N Ingle, Matthew P Goetz
Abstract: #PD2-05
Spotlight Poster Discussion 2: Wednesday, December 9th: 5:15-6:30pm CT
TBCRC 038: The Human Tumor Atlas Network (HTAN) Breast PreCancer Atlas: A multi-omic integrative analysis of ductal carcinoma in situ (DCIS) and correlation with clinical outcomes
Siri H Strand, Belen Rivero, Lorraine King, Tyler Risom, Bryan Harmon, Fergus Couch, Kristalyn Gallagher, Mark Kilgore, Gabrielle Rocque, Angela DiMichelle, Tari King, Priscilla McAuliffe, Julie Nangia, Joanna Lee, Rita Nanda, Ana Maria Storniolo, Alastair Thompson, Gaorav Gupta, Robyn Burns, Antonio Wolff, Chunfang Zhu, Jason Wang, Shirley X Zhu, Jose Seoane, Jen Tappenden, Daisy Ding, Dadong Zhang, Jingqin Luo, Sujay Vennam, Sushama Varma, Lunden Simpson, Luis Cisneros, Timothy Hardman, Lauren Anderson, Cody Straub, Sucheta Srivastava, Deb J Veis, Christina Curtis, Rob Tibshirani, Robert Michael Angelo, Allison Hall, Kouros Owzar, Kornelia Polyak, Carlo Maley, Jeff Marks, Graham Colditz, Shelley Hwang, Robert B West
Abstract: #PD5-08
Spotlight Poster Discussion 5: Thursday, December 10th; 2:15-3:30pm CT
2020 Society for Neuro-Oncology (SNO) Annual Meeting
(November 19-22nd)
TBCRC 049: A Phase II Non-randomized Study to Assess the Safety and Efficacy of the Combination of Tucatinib and Trastuzumab and Capecitabine for Treatment of Leptomeningeal Metastases in HER2-positive Breast Cancer
Barbara J O’Brien, Rashmi K Murthy, Donald Berry, Nicholas Navin, Jason Johnson, Maria Gule-Monroe, Jose P Leone, Jennifer Specht, Michelle Melisko, Aki Morkikawa, Anna M Storniolo, Adam Brufsky, Paula R Pohlmann, Deric M Park, Ben H Park, Ian Krop, Nancy U Lin, Mothaffar F Rimawi, Antonio Wolff, Andres Forero-Torres, Erica Stringer-Reasor
Abstract: #CTNI-02
Poster: available on-demand
American Society of Clinical Oncology (ASCO) 2020 Annual Meeting
(all available on demand, beginning on Friday, May 29th at 8am ET)
TBCRC 023: A multiparameter classifier to predict response to lapatinib plus trastuzumab (LT) without chemotherapy in HER2-positive breast cancer
Jamunarani Veeraraghavan, Carolina Gutierrez, Carmine De Angelis, Tao Wang, Tomás Pascual, Britta Weigelt, Patricia Galvan, Brent Neil Rexer, Andres Forero-Torres, Antonio C. Wolff, Rita Nanda, Anna Maria Storniolo, Ian E. Krop, Matthew P. Goetz, Jorge S. Reis-Filho, Susan G. Hilsenbeck, Aleix Prat, C. Kent Osborne, Rachel Schiff, Mothaffar F. Rimawi
Abstract: #1011
Clinical Science Symposium: Steps Forward and Lessons Learned: Using Biomarkers to Guide Targeted Therapies in Breast Cancer, The Dr. Bernard Fisher Memorial Annual Clinical Science Symposium supported by the Breast Cancer Research Foundation
TBCRC 043: A phase II trial of azetolizumab (anti-PDL1) with carboplatin in patients with metastatic triple-negative breast cancer (mTNBC)
Eric Michael Lander, Brian David Lehmann, Payal D Shah, Elizabeth Claire Dees, Tarah Jean Ballinger, Paula Raffin Pohlmann, Cesar Augusto Santa-Maria, Yu Shyr, Ingrid A. Mayer, Ben Ho Park, Jennifer A. Pietenpol, Vandana G Abramson
Abstract: #TPS1112
Session Title: Breast Cancer- Metastatic
Immunotherapy and chemotherapy combination for chest wall disease: TBCRC 044 trial Neelima Vidula, Rita Nanda, Kathy Miller, Paula Raffin Pohlmann, Vandana G Abramson, Leisha A. Emens, Ben Ho Park, Minetta C. Liu, Andrei Goga, Hope S. Rugo
Abstract: #TPS1114
Session Title: Breast Cancer- Metastatic
TBCRC 048: A phase II study of olaparib monotherapy in metastatic breast cancer patients with germline or somatic mutations in DNA damage response (DDR) pathway genes (Olaparib Expanded)
Nadine M. Tung, Mark E. Robson, Steffen Ventz, Cesar Augusto Santa-Maria, Paul Kelly Marcom, Rita Nanda, Payal D Shah, Tarah Jean Ballinger, Eddy Shih-Hsin Yang, Michelle E. Melisko, Adam Brufsky, Shaveta Vinayak, Michelle Demeo, Colby Jenkins, Susan M. Domchek, Gerburg M. Wulf, Ian E. Krop, Antonio C. Wolff, Eric P. Winer, Judy Ellen Garber
Abstract: #1002
Oral Abstract Session: Breast Cancer- Metastatic
2020 Publications
TBCRC 002: A Phase II, Randomized, Open-Label Trial of Preoperative Letrozole with or without Bevacizumab in Postmenopausal Women with Newly Diagnosed Stage 2/3 Hormone Receptor-Positive and HER2-negative Breast Cancer
Christos Vaklavas, Brian S. Roberts, Katherine E. Varley, Nancy U. Lin, Minetta C. Liu, Hope S. Rugo, Shannon Puhalla, Rita Nanda, Anna Maria Storniolo, Lisa A. Carey, Mansoor N. Saleh, Yufeng Li, Jennifer F. Delossantos, William E. Grizzle, Albert F. LoBuglio, Richard M. Myers, Andres Forero-Torres
Breast Cancer Res, 2020 Feb 18; PMID: 32070401
Clinical Evaluation of Germline Polymorphisms Associated with Capecitabine Toxicity in Breast Cancer - TBCRC 015
Peter H. O’Donnell, Vassily Trubetskoy, Ashley Nurhussein-Patterson, Julianne P. Hall, Aritro Nath, Dezheng Huo, Gini F. Fleming, James N. Ingle, Vandana Abramson, PK Morrow, Anna Maria Storniolo, Andres Forero, Catherine Van Poznak, Minetta C. Liu, Jenny C. Chang, Douglas E. Merkel, Jeffrey M. Peppercorn, Hope S. Rugo, E. Claire Dees, Olwen M. Hahn, Philip C. Hoffman, Gary L. Rosner, R. Stephanie Huang, Mark J. Ratain, Nancy Cox, Olufunmilayo I. Olopade, Antonio C. Wolff, M. Eileen Dolan, and Rita Nanda
Breast Cancer Res Treat, 2020 Jun; PMID: 32378051
TBCRC 023: A Randomized Phase II Neoadjuvant Trial of Lapatinib Plus Trastuzumab Without Chemotherapy for 12 Versus 24 Weeks in Patients With HER2-Positive Breast Cancer
Mothaffar F. Rimawi, Polly A. Niravath, Tao Wang, Brent Rexer, Andres Forero, Antonio C. Wolff, Rita Nanda, Anna M. Storniolo, Ian E. Krop, Matthew P. Goetz, Julie R. Nangia, Sao Jiralerspong, Anne C. Pavlick, Carmine De Angelis, Carolina Gutierrez, Rachel Schiff, Susan G. Hilsenbeck, and C. Kent Osborne
Clin Cancer Res, 2020 Feb15; PMID: 31662331
TBCRC 030: A Phase II Study of Preoperative Cisplatin vs. Paclitaxel in Triple-Negative Breast Cancer: Evaluating the Homologous Recombination Deficiency (HRD) Biomarker
EL Mayer, V Abramson, R Jankowitz, C Falkson, PK Marcom, T Traina, L Carey, M Rimawi, J Specht, K Miller, V Stearns, N Tung, C Perou, AL Richardson, K Componeschi, L Trippa, Z Tan-Wasielewski, K Timms, I Krop, AC Wolff, EP Winer
Ann Oncol, 2020 Nov; PMID: 32798689
TBCRC 031: Randomized Phase II Study of Neoadjuvant Cisplatin Versus Doxorubicin-Cyclophosphamide in Germline BRCA Carriers With HER2-Negative Breast Cancer (The INFORM Trial)
Nadine Tung, Banu Arun, Michele R Hacker, Erin Hofstatter, Deborah L Toppmeyer, Steven J Isakoff, Virginia Borges, Robert D Legare, Claudine Isaacs, Antonio C Wolff, Paul Kelly Marcom, Erica L Mayer, Paulina B Lange, Andrew J Goss, Colby Jenkins, Ian E Krop, Eric P Winer, Stuart J Schnitt, Judy E Garber
J Clin Oncol, 2020 May 10; PMID: 32097092
TBCRC 032 IB/II Multicenter Study: Molecular insights to androgen receptor antagonist and PI3K inhibitor efficacy in metastatic triple-negative breast cancer patients
Lehmann BD, Abramson VG, Sanders M, Mayer EL, Haddad T, Nanda R, Van Poznak C, Storniolo AM, Nangia JR, Gonzalez-Ericsson PI, Sanchez V, Johnson KN, Abramson RG, Chen SC, Shyr Y, Arteaga CL, Wolff AC, Pietenpol JA
Clin Cancer Res, 2020 May 1; PMID: 31822498
The Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In Situ in Patients with Intraductal Papilloma without Atypia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 034)
Faina Nakhlis, Gabrielle M Baker, Melissa Pilewskie, Rebecca Gelman, Katherina Z Calvillo, Kandice Ludwig, Priscilla F McAuliffe, Shawna Willey, Laura H Rosenberger, Catherine Parker, Kristalyn Gallagher, Lisa Jacobs, Sheldon Feldman, Paulina Lange, Stephen D DeSantis, Stuart J Schnitt, Tari A King
Ann Surg Oncol, 2020 Oct 12; PMID: 33047246
Patient-reported Outcomes in the Translational Breast Cancer Research Consortium
Deborah Bowen, Eileen Shinn, Sophie Gregrowski, Gretchen Kimmick, Laura S. Dominici, Elizabeth S. Frank, Karen Lisa Smith, Gabrielle Rocque, Kathryn J. Ruddy, Teri Pollastro, Michelle Melisko, Tarah J. Ballinger, Oluwadamilola M. Fayanju, Antonio C. Wolff
Cancer, 2020 Mar 1; PMID 31743427