2022 San Antonio Breast Cancer Symposium (SABCS)
(December 6-10th in San Antonio, TX)

Using Clinical Characteristics and Molecular Markers to Predict the Risk of Subsequent Ipsilateral Breast Events after Excision of DCIS (TBCRC 038)
Liu Y, Strand SH, King L, Harmon B, Couch FJ, Gallagher K, Kilgore M, Wei S, DeMichele A, King T, McAuliffe PF, Marks J, Maley C, West R, Hwang ES, Colditz GA
Poster Session 1 from 5-6:15pm CT in Hall 1
Poster: P1-07-02

Translational Breast Cancer Research Consortium Trial 022 (TBCRC 022): Neratinib and Trastuzumab-Emtansine (T-DM1) for HER2+ Breast Cancer Brain Metastases (BCBM)
Freedman R, Ren S, Tayob N, Gelman R, Smith KL, Davis R, Pereslete A, Attaya V, Cotter C, Chen WY, Santa-Maria CA, Van Poznak C, Moy B, Brufsky AM, Melisko M, O'Sullivan CC, Ashai N, Rauf Y, Nangia J, Trapani D, Savoie J, Burns R, Wolff AC, Winer EP, Rimawi MF, Krop I, Lin NU
Spotlight Poster Discussion Session 7 from 5-6:15pm CT in Stars at Night Ballroom 3&4
Poster Discussion: PD7-03

TBCRC-055: A Phase II Study of NirAparib, Dostarlimab, and Radiotherapy in Metastatic, PD-L1 Negative or Immunotherapy-Refractory Triple-Negative Breast Cancer (NADiR)
Scott E, Isakoff SJ, Taghian AG, Wright J, Augusto Santa-Maria C, Shah PD, Taunk N, Anders C, Blitzblau R, Gupta G, Ho A
Ongoing Trials Poster Session 2 at 5pm CT
Poster: OT2-09-01

Circulating Tumor DNA Association with Residual Cancer Burden After Neoadjuvant Therapy in Triple Negative Breast Cancer in TBCRC 030
Parsons HA, Blewett T, Chu X, Sridhar S, Santos K, Xiong K, Abramson V, Patel A, Cheng J, Brufsky AM, Rhoades J, Force J, Liu R, Traina TA, Carey LA, Rimawi MF, Elkhanany A, Stearns V, Specht JM, Burstein H, Wolff AC, Winer EP, Tayob N, Krop I, Golub T, Mayer EL
Spotlight Poster Discussion Session 11 from 7-8:15am CT in Stars at Night Ballroom 1&2
Poster Discussion: PD11-06

Intratumor Heterogeneity and Intrinsic Immune Activation are Associated with Response to Chemotherapy in BRCA-related Breast Cancers (TBCRC 031)
Batalini F, Gulhan DC, Katopodi XL, Kalavros N, Tran A, Karagkouni D, Stern-Gatof e, Schnitt S, Garber JE, Wulf GM, Park PJ, Vlachos I, Tung N
Poster Session 5 from 5-6:15pm CT in Hall 1
Poster: P5-12-03

TBCRC-053: P-RAD: A Randomized Study of Preoperative Chemotherapy, Pembrolizumab and No, Low or High Dose RADiation in Node-Positive, HER2-Negative Breast Cancer
Connolly JJ, Spring LM, Taghian AG, Gadd M, Warren L, Garrido-Castro AC, King T, Mittendorf EA, Leone JP, Casey DL, Carey LA, Traina TA, Abdou Y, Khan A, Plitas G, Wright J, Santa-Maria CA, Jacobs L, Blitzblau R, Hwang ES, Anders C, Krop I, Wolff AC, Thompson AM, Denault E, Gupta G, Ho A
Ongoing Trials Poster Session 3 at 5pm CT
Poster: OT3-15-01

Adjuvant Trastuzumab Emtansine (T-DM1) Versus Paclitaxel plus Trastuzumab (TH) for Stage I HER2+ Breast Cancer: 5-Year Results and Correlative Analyses from ATEMPT (TBCRC033)
Tarantino P, Tayob N, Dang CT, Yardley D, Isakoff SJ, Valero V, Faggen M, Mulvey T, Bose R, Weckstein D, Wolff AC, Reeder-Hayes K, Rugo HS, Ramaswamy B, Zuckerman D, Hart L, Gadi VK, Constantine M, Cheng K, Garrett AM, Marcom PK, Albain KS, DeFusco P, Tung N, Ardman B, Nanda R, Jankowitz RC, Rimawi MF, Abramson V, Pohlmann P, Van Poznak C, Forero-Torres A, Liu MC, Ruddy KJ, Zheng Ym Barroso-Sousa R; Waks A, DeMeo MK, DiLullo MK, Curigliano G, Burstein H, Partridge AH, Winer EP, Viale G, Hui W, Mittendorf EA, Schneider BP, Prat A, Krop I, Tolaney SM
Spotlight Poster Discussion Session 18 from 7-8:15am CT in Stars at Night Ballroom 3&4
Poster Discussion: PD18-01

Reasons for Reduced Willingness to Participate in Clinical Trials During the COVID-19 Pandemic:  The Translational Breast Cancer Research Consortium (TBCRC) 057 Survey  
Smith KL, Mead-Harvey C, Mazza GL, Holler AE, Shinn E, Frank E, Melisko M, Eaton C, Salamone JM, Pollastro T, Spears P, Wolff AC, Rocque GB
Poster Session 6 from 7-8:15am CT in Hall 1
Poster: P6-08-07

ESMO Congress 2022
(September 9-13th, 2022 in Paris, France)

Correlation of early change in standardized uptake value (SUV) on positron emission tomography (PET/CT) with recurrence-free survival (RFS) and overall survival (OS) in patients with primary operable HER2-positive breast cancer (TBCRC026)
Hennessy M, Leal JP, Huang CY, Solnes L, Denbow R, Abramson V, Carey L, Liu M, Rimawi M, Specht J, Storniolo AM, Valero V, Vaklavas C, Winer EP, Krop IE, Wolff AC, Cimino-Mathews A, Wahl RL, Stearns V, Connolly RM
Poster Session 02: September 10th, 2022

Metastatic Breast Cancer Research Conference
(September 7-9th, 2022 in Park City, UT)

Multiplatform analysis of matched primary and metastatic breast tumors from the AURORA US Network identifies microenvironment differences as potential drivers of metastasis (Aurora Retrospective Trial)
Susana Garcia-Recio, Toshinori Hinoue, Gregory L Wheeler, Benjamin J. Kelly, Justin M. Balko, Katherine A. Hoadley, Peter W. Laird, Elaine R. Mardis, Lisa A. Carey, Charles M. Perou, and the AURORA US Network
Oral Presentation

American Society of Clinical Oncology (ASCO) 2022 Annual Meeting
(June 3rd-7th, 2022 in Chicago, IL)

Exploring Homologous Recombination Deficiency Thresholds for Predicting Response to Platinum-Based Treatment in Triple Negative Breast Cancer (TBCRC 008 & 030)
Kirsten M. Timms; Lauren Lenz; Elizabeth S. Cogan; Erica L. Mayer; Virginia G. Kaklamani; Vered Stearns; Vandana Abramson; Carla Falkson; Rachel Jankowitz; P. Kelly Marcom; Nadine Tung; James M. Ford; Shaveta Vinayak; Judy C Boughey; Matthew P Goetz; Anna Maria Storniolo; Roisin M. Connolly; Andrea Richardson; Melinda Telli
Abstract: #525; Poster: #297
June 6th, 2022, 9am EDT; Hall A (in person & on demand)

TBCRC 057:  An online survey about anxiety and willingness to participate in breast cancer clinical trials during the COVID-19 pandemic
Karen Lisa Smith, Gina Mazza, Carolyn Mead-Harvey, Eileen Shinn, Elizabeth Frank, Michelle Melisko, Cyd Eaton, Jeannine Salamone, Terri Pollastro, Patricia A. Spears, Antonio Wolff, Gabrielle Rocque
Abstract: #1564; Poster: #156
June 4th, 2022; 2:15pm EDT; Hall A (in person & on demand)

American Association for Cancer Research (AACR) 2022 Annual Meeting
(April 8-13th, 2022 in New Orleans, LA)

Multiplatform Analysis of Matched Primary and Metastatic Breast Tumors from the Aurora US Network Identifies Microenvironment Features as Drivers of Metastasis (Aurora Retrospective Trial)
Susana Garcia Recio, Toshinori Hinoue, Gregory L. Wheeler, Benjamin J. Kelly, Justin M. Balko, Katherine A. Hoadley, Peter W. Laird, Elaine R. Mardis, Charles M. Perou
Abstract: #LB176/4 (in Session LBMS01- Minisymposium: Late-Breaking Research)
Oral Presentation: Tuesday, April 12th: 3:20-3:35pm CT [Room 217-219, Convention Center]

2022 Publications

Cardiac Outcomes of Subjects on Adjuvant Trastuzumab Emtansine vs Paclitaxel in Combination with Trastuzumab for Stage I HER2-Positive Breast Cancer (ATEMPT study) [TBCRC 033]
Romualdo Barroso-Sousa; Paolo Tarantino; Nabihah Tayob; Chau Dang; Denise A. Yardley; Steven J. Isakoff; Vicente Valero; Meredith Faggen; Therese Mulvey; Ron Bose; Jiani Hu; Douglas Weckstein; Antonio C. Wolff; Katherine Reeder-Hayes; Hope S. Rugo; Bhuvaneswari Ramaswamy; Dan Zuckerman; Lowell Hart; Vijayakrishna K. Gadi; Michael Constantine; Kit Cheng; Frederick Briccetti; Bryan Schneider; Audrey Merrill Garrett; Kelly Marcom; Kathy Albain; Patricia DeFusco; Nadine Tung; Blair Ardman; Rita Nanda; Rachel C. Jankowitz; Mothaffar Rimawi; Vandana Abramson; Paula R. Pohlmann; Catherine Van Poznak; Andres Forero-Torres; Minetta Liu; Kathryn Ruddy; Yue Zheng; Shoshana M. Rosenberg; Richard D. Gelber; Lorenzo Trippa; William Barry; Michelle DeMeo; Harold Burstein; Ann Partridge; Eric P. Winer; Ian Krop; Sara M. Tolaney
NPJ Breast, 2020 Feb 16; PMID: 35173164

Local therapy outcomes and toxicity from the ATEMPT trial (TBCRC 033): A phase II randomized trial of adjuvant trastuzumab emtansine vs. paclitaxel in combination with trastuzumab in women with stage I HER2-positive breast cancer
Jennifer R. Bellon, MD; Nabihah Tayob, PhD; David D. Yang, MD; Jordan Tralins; Chau T. Dang, MD; Steven J. Isakoff, MD, PhD; Michelle DeMeo, BS; Harold J. Burstein, MD, PhD; Ann H. Partridge, MD, MPH; Eric P. Winer, MD; Ian E. Krop, MD, PhD; Sara M. Tolaney, MD, MPH
Int J Radiat Oncol Biol Phys, 2020 May 1; PMID:  34990776