2023 San Antonio Breast Cancer Symposium (SABCS)
(December 5-9th, 2023 in San Antonio, TX)
The STOP-HER2 Trial: A Phase 2 Study of Stopping Trastuzumab in Patients with HER2+ Metastatic Breast Cancer (TBCRC 062)
Parsons HA, Morganti S, Ruddy KJ, Smith KL, Attaya V, Kallfelz EA, DeMeo MK, LaScala J, Pollastro T, Mertz S, Spears P, Brufsky A, Dang C, Dent S, Elkhanany A, Gwin W, O'Sullivan CC, Miller K, Nunnery S, Walsh EM, Storniolo AM, Tolaney SM, Tayob N, Wolff AC, Winer EP, Rimawi MF, Krop IE, Lin NU
Poster Session 2: 5:00-7:00pm CT in Halls 2-3
Poster: PO2-20-01
AVIATOR/TBCRC 045: A randomized phase II study of vinorelbine (N) + trastuzumab (H) alone or combined with avelumab (A) +/- utomilumab (U) in patients (pts) with HER2+ metastatic breast cancer (MBC) (NCT03414658)
Waks AG, Shi R, Regan M, Dang C, Santa-Maria C, Westbrook K, Abramson V, Murthy R, Nanda R, Rugo HS, Clark AS, Mainor C, Dees EC, Hoyos V, Miller K, Stringer-Reasor E, Hunter N, Oh SY, DeMeo M, Okpoebo A, Elias E, Kurt BB, Lin NU, Rimawi MF, Wolff AC, Mittendorf E, Goel S, Tolaney SM, Loi S, Krop IE
Rapid Fire Session 2- Mini-Oral Presentations: 12:00-12:45pm CT in Hall 1
Oral Presentation: RF02-06
ESMO Congress 2023
(October 20-24th, 2023 in Madrid, Spain)
Evaluation of a composite PET/CT and HER2 tissue-based biomarker to predict response to neoadjuvant HER2-directed therapy in early breast cancer (TBCRC026)
Hennessy MA, Carter JM, Kachergus JM, Ma Y, Leal JP, Solnes LB, Cimino-Mathews A, Abramson VG, Carey LA, Rimawi M, Specht J, Storniolo AM, Vaklavas C, Wolff AC, Wahl RL, Perez EA, Huang C, Stearns V, Thompson EA, Connolly RM
Poster Session 02: October 21st, 2023
Poster: 333P
2023 Publications
Identifying homologous recombination deficiency in breast cancer: genomic instability score distributions differ among breast cancer subtypes [TBCRC 008 & 030]
Lauren Lenz, Chris Neff, Cara Solimeno, Elizabeth S. Cogan, Vandana Abramson, Judy C Boughey, Carla Falkson, Matthew P Goetz, James Ford, William J. Gradishar, Rachel Jankowitz, Virginia G. Kaklamani, P. Kelly Marcom, Andrea L. Richardson, Anna Maria Storniolo, Nadine Tung, Shaveta Vinayak, Darren R. Hodgson, Zhongwu Lai, Simon Dearden, Bryan Hennessy, Erica L. Mayer, Gordon Mills, Paul Bartel, Thomas P. Slavin, Alexander Gutin, Roisin M Connolly, Melinda Telli, Vered Stearns, Jerry S. Lanchbury, Kirsten M Timms
Breast Cancer Res Treat., 2023 Nov; PMID: 37589839
A multiparameter molecular classifier to predict response to neoadjuvant lapatinib plus trastuzumab without chemotherapy in HER2+ breast cancer [TBCRC 023]
Jamunarani Veeraraghavan, Carolina Gutierrez, Carmine De Angelis, Robert Davis, Tao Wang, Tomas Pascual, Pier Selenica, Katherine Sanchez, Anne C. Pavlick, Patricia Galvan, Brent Rexer, Andres Forero, Rita Nanda, Anna M. Storniolo, Ian E. Krop, Matthew P. Goetz, Julie R. Nangia, Antonio C Wolff, Britta Weigelt, Jorge Reis-Filho, Susan G. Hilsenbeck, Aleix Prat, C. Kent Osborne, Rachel Schiff, Mothaffar F. Rimawi
Clin Cancer Res, 2023 Aug 15; PMID: 37195235
Correlation of SUV on early interim PET with recurrence-free survival and overall survival in primary operable HER2-positive breast cancer (TBCRC 026)
Maeve A. Hennessy, Jeffrey P. Leal, Chiung-Yu Huang, Lilja B. Solnes, Rita Denbow, Vandana G. Abramson, Lisa A. Carey, Minetta C. Liu, Mothaffar Rimawi, Jennifer Specht, Anna Maria Storniolo, Vicente Valero, Christos Vaklavas, Eric P. Winer, Ian E. Krop, Antonio C Wolff , Ashley Cimino-Mathews, Richard L. Wahl, Vered Stearns, Roisin M. Connolly
J Nucl Med, 2023 Nov; PMID: 37652539
Quality of life in male breast cancer: prospective study of the international male breast cancer program (EORTC10085/TBCRC 029/BIG2-07/NABCG)
Carolien P Schröder, Elise van Leeuwen-Stok, Fatima Cardoso, Barbro Linderholm, Coralie Poncet, Antonio C Wolff, Vesna Bjelic-Radisic, Gustavo Werutsky, Miguel H Abreu, Ivana Bozovic-Spasojevic, Irma den Hoed, Aafke H Honkoop, Maartje Los, Jose P Leone, Nicola S Russell, Tineke J Smilde, Annette WG van der Velden, Catherine Van Poznak, Marije M Vleugel, Rachel L Yung, Corneel Coens, Sharon H Giordano, Kathryn J Ruddy
Oncologist, 2023 Oct 3; PMID: 37310797
Single duplex DNA sequencing with CODEC detects mutations with high sensitivity [TBCRC 030]
Jin H. Baey, Ruolin Liuy, Eugenia Roberts, Erica Nguyen, Shervin Tabrizi, Justin Rhoades, Timothy Blewett, Kan Xiong, Gregory Gydush, Douglas Shea, Zhenyi An, Sahil Patel, Ju Cheng, Sainetra Sridhar, Heather A. Parsons, Erica L. Mayer, G. Mike Makrigiorgos, Todd R. Golub, Viktor A. Adalsteinsson
Nat Genet, 2023 May; PMID: 37106072
Circulating tumor DNA association with residual cancer burden after neoadjuvant chemotherapy in triple-negative breast cancer in TBCRC 030
HA Parsons, T Blewett, X Chu, S Sridhar, K Santos, K Xiong, V G Abramson, A Patel, J Cheng, A Brufsky, J Rhoades, J Force, R Liu, T A Traina, L A Carey, M F Rimawi, K D Miller, V Stearns, J Specht, C Falkson, H J Burstein, A C Wolff, E P Winer, N Tayob, I E Krop, G M Makrigiorgos, T R Golub, E L Mayer, V A Adalsteinsson
Annals of Oncology,2023 October; PMID: 37597579
Evaluation of alisertib alone or combined with fulvestrant in patients with endocrine-resistant advanced breast cancer: the phase 2 TBCRC 041 randomized clinical trial
Tufia C Haddad, Vera J Suman, Antonino B D’Assoro, Jodi M Carter, Karthik V Giridhar, Brendan P McMenomy, Katelyn Santo, Erica L Mayer, Meghan S Karuturi, Aki Morikawa, P Kelly Marcom, Claudine J Isaacs, Sun Young Oh, Amy S Clark, Ingrid A Mayer, Khandan Keyomarsi, Timothy J Hobday, Prema P Peethambaram, Ciara C O’Sullivan, Roberto A Leon-Ferre, Minetta C Liu, James N Ingle, Matthew P Goetz
JAMA Oncol, 2023 Jun 1; PMID: 36892847