2024 San Antonio Breast Cancer Symposium (SABCS)
(December 10-13th, 2024 in San Antonio, TX)

MARGOT/TBCRC052: A randomized phase II trial comparing neoadjuvant paclitaxel/margetuximab/pertuzumab (TMP) vs paclitaxel/trastuzumab/pertuzumab (THP) in patients (pts) with stage II-III HER2+ breast cancer
Adrienne G. Waks, Hillary Heiling, Paula Pohlmann, Mothaffar Rimawi, Natalie Sinclair, Rachel L. Yung, Jesus Anampa, Claudine Isaacs, Thomas O’Connor, Nadine Tung, Adam Brufsky, Lisa Carey, Rita Nanda, Nancy U. Lin, Antonio Wolff, Clare Strickland, Michelle DeMeo, Ashley Root, Tasnim Rahman, Abigail Recko, Molly DiLullo, Ashka Patel, Esther R. Ogayo, Philip Poorvu, Antonio Giordano, Erica Mayer, Tari King, Eric P. Winer, Elizabeth Mittendorf, Nabihah Tayob, Sara M. Tolaney, Ian E. Krop
Late-Breaking Oral Presentations: 6:00-7:00pm CT in Stars at Night 1-2
Oral Presentation: LB1-02

A Randomized Phase II Window-of-opportunity Trial of Ruxolitinib in Patients with High Risk and Premalignant Breast Conditions (TBCRC 042)
Julie Nangia, Shaun Basura, Tao Wang, Amy Ku, Derek Thomas, Ingrid Meszoely, Parijatham S. Thomas, Catherine Parker, Sheldon Feldman, Carla Fisher, Kristalyn Gallagher, Gaorav Gupta, Alastair Thompson, Kristen Otte, Carolina Gutierrez, Chandandeep Nagi, George Miles, Susan Hilsenbeck, Yi Li, Kent Osborne, Mothaffar Rimawi
Poster Session 2: 5:30-7:00pm CT in Halls 2-3
Poster: P2-12-19

TBCRC 058: A Randomized Phase II Study of Enzalutamide, Enzalutamide with Mifepristone, and Treatment of Physician’s Choice in Patients with Androgen Receptor-Positive Metastatic Triple-Negative or Estrogen Receptor-Low Breast Cancer (NCT06099769)
Rita Nanda, Yuan Chen, Katia Khoury, Hope S. Rugo, Erica L. Mayer, Lisa A. Carey, Michelle Melisko, Angemael Syldor, Chaya Friedman, Jennifer Savoie, Fresia Pareja, Britta Weigelt, Sarat Chandarlapaty, Nicholas Turner, Joshua Lang, Marina Sharifi, Suzanne Conzen, Tiffany Traina
Poster Session 3: 12:30-2:00pm CT in Halls 2-3
Poster: P3-08-17

Endocrine Response in Women with Invasive Lobular Carcinoma (TBCRC 037): A Multicenter Randomized Clinical Trial
Priscilla F. McAuliffe, Beth Z. Clark, Tina Hieken, Rita A. Mukhtar, Hannah Linden, Julie Nangia, Kristalyn Gallagher, Erica Stringer-Reasor, Isabelle Bedrosian, Sheldon Feldman, Rita Nanda, Ian Greenwalt, Jami Rothman, H. Thorpe, Curtis Tatsuoka, Adrian V. Lee, Alastair Thompson, Nancy E. Davidson, Steffi Oesterreich, Rachel C. Jankowitz
Concurrent Poster Spotlight Sessions; Session 18: 5:30-7:00pm CT in Stars at Night 3-4; Poster Viewing 5:30-6pm CT
Poster: PS18-09

TBCRC 056: A phase II study of neoadjuvant niraparib with dostarlimab for patients with BRCA- or PALB2-mutated breast cancer: Results from the ER+/HER2- cohort
Erica L. Mayer, Noah Graham, Roberto Leon-Ferre, Mariya Rozenblit, Cesar Santa-Maria, Steven Isakoff, Jennifer Specht; Nadine Tung, Vandana Abramson, Jennifer Desrosiers, Beyza Koca, Sara Tolaney, Eric Winer, Ian Krop, Antonio Wolff, Geoffrey I. Shapiro, Nabihah Tayob, Jennifer L. Guerriero
Rapid Fire 3: 12:00-12:50pm CT in Hall 1
Oral Presentation: RF3-01

2024 American Society of Clinical Oncology (ASCO)
(May 31st – June 4th, 2024 in Chicago, IL)

RNA-Seq based gene expression profiling of baseline and on-treatment breast tumors to predict response to HER2-directed therapy, without chemotherapy (TBCRC026)
Maeve Hennessy, Aranzazu Fernández, Chiung Yu Huang, Ashley Cimino-Mathews, Rita Denbow, Vandana Abramson, Mothaffar Rimawi, Jennifer Specht, Anna Storniolo, Vicente Valero, Chris Vaklavas, Eric Winer, Ian Krop, Antonio Wolff, Richard Wahl, E Thompson, Vered Stearns, Charles Perou, Lisa Carey, Roisin Connolly
Poster Session: 9am-12pm CT in Hall A
Poster Board: 122
Abstract: 530

Correlation of TILs indices generated by visual review and digital computational algorithm with outcomes from preoperative chemotherapy for TNBC in TBCRC 030
Guilherme Nader Marta, Xiangying Chu, Satabhisa Mukhopadhyay, Vandana Abramson, Adam Brufsky, Erica Stringer-Reasor, Susan Dent, Tiffany Traina, Lisa Carey, Mothaffar Rimawi, Jennifer Specht, Kathy Miller, Cesar Santa-Maria, Tathagata Dasgupta, Busem Binboğa Kurt, Nabihah Tayob, Ian Krop, Nadine Tung, Stuart Schnitt, Erica Mayer
Poster Session: 9am-12pm CT in Hall A
Poster Board: 147
Abstract: 555

Molecular profiling of serial liquid biopsy specimens utilizing cell free DNA (cfDNA) and circulating tumor cells (CTCs) in TBCRC 041: A phase II study of alisertib in endocrine resistant metastatic breast cancer (MBC)
Karthik Giridhar, Vera Suman, Xiaojia Tang, Hong Ye, Jordan Campbell, Erica Mayer, Meghan Karuturi, Aki Morikawa, Gretchen Kimmick, Claudine Isaacs, Sun Young Oh, Amy Clark, Ben Park, Leslie Bucheit, Jill Tsai, James Ingle, Matthew Goetz, Antonino D'assoro, Krishna Kalari, Tufia Haddad
Poster Session: 9am-12pm CT in Hall A
Poster Board: 15
Abstract: 1037

Tucatinib-trastuzumab-capecitabine for treatment of leptomeningeal metastasis in HER2+ breast cancer: TBCRC 049 phase 2 study results
Barbara O'Brien, Rashmi Murthy, Donald Berry, Akshara Singareeka Raghavendra, Maria Gule-Monroe, Jason Johnson, Jill Schwartz-Gomez, Ariel Topletz-Erickson, Mina Lobbous, Michelle Melisko, Aki Morikawa, Sherise Ferguson, John de Groot, Ian Krop, Vicente Valero, Mothaffar Rimawi, Antonio Wolff, Debashish Tripathy, Nancy Lin, Erica Stringer-Reasor
Rapid Oral Abstract Session:  11:30am-1:00pm CT in E350
Oral Presentation Time: 12:08-12:14pm CT
Abstract: 2018

TBCRC 058: A randomized phase II study of enzalutamide, enzalutamide with mifepristone, and treatment of physician’s choice in patients with androgen receptor-positive metastatic triple-negative or estrogen receptor-low breast cancer (NCT06099769)
Tiffany Traina, Yuan Chen, Katia Khoury, Hope Rugo, Erica Mayer, Lisa Carey, Michelle Melisko, Angemael Syldor, Chaya Friedman, Jennifer Savoie, Fresia Pareja, Britta Weigelt, Sarat Chandarlapaty, Nicholas Turner, Suzanne Conzen, Rita Nanda
Poster Session: 9am-12pm CT in Hall A
Poster Board: 107a
Abstract: TPS1138

ETHAN: A phase II study comparing different endocrine therapies for male breast cancer (TBCRC 059)
Jose Leone, Kathryn Ruddy, Naim Rashid, Sharon Giordano, Gaorav Gupta, Susan Hilsenbeck, Ayca Gucalp, Elaine Walsh, Jasmine Sukumar, Igor Makhlin, Tamara Ortiz-Perez, Philip Spanheimer, Benjamin Calhoun, Antonio Wolff, Ian Krop, Alastair Thompson
Poster Session: 9am-12pm CT in Hall A
Poster Board: 213b
Abstract: TPS632

TBCRC 048 (olaparib expanded) expansion cohorts: Phase 2 study of olaparib monotherapy in patients (pts) with metastatic breast cancer (MBC) with germline (g) mutations in PALB2 or somatic (s) mutations in BRCA1 or BRCA2
Nadine Tung, Mark Robson, Rita Nanda, Tianyu Li, Shaveta Vinayak, Payal Shah, Katia Khoury, Gretchen Kimmick, Cesar Santa-Maria, Adam Brufsky, Michelle DeMeo, Joao Vieira, Lisa Carey, Gerburg Wulf, Susan Domchek, Ian Krop, Antonio Wolff, Eric Winer, Judy Garber
Rapid Oral Abstract Session:  11:30am-1:00pm CT in Hall D1
Oral Presentation Time: 12:36-12:42pm CT
Abstract: 1021

Society of Surgical Oncology (SSO) 2024
(March 20th-23rd, 2024 in Atlanta, GA)

The Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or DCIS in Patients Diagnosed with Flat Epithelial Atypia by Core Needle Biopsy (TBCRC 034)
Faina Nakhlis; Gabrielle Baker; Tianyu Li; Rebecca Gelman; George Plitas; Kandice Ludwig; Priscilla McAuliffe; Claudine Isaacs; Shelley Hwang; Kristalyn Gallagher; Lisa Jacobs; Suniti N.Nimbkar; Sheldon Feldman; Paulina Lange; Victoria Attaya; Michelle DeMeo; Ashton Fraettarelli; Stuart Schnitt; Tari A. King
Oral Presentation

2024 Publications

Neratinib   and Ado-Trastuzumab-Emtansine for HER2-positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium Trial 022 – Cohort 4 Results
Rachel A Freedman, Hillary Heiling, Tianyu Li, Dario Trapani, Nabihah Tayob, Rebecca S. Gelman, Karen L. Smith ,  Raechel Davis, Alyssa Pereslete, Michelle K. DeMeo, Christine Cotter,  Wendy Y. Chen, Heather A. Parsons, Cesar A. Santa-Maria, Catherine Van Poznak, Beverly Moy, Adam M. Brufsky, Michelle E. Melisko, Ciara C. O’Sullivan, Nadia Ashai, Yasmeen Rauf, Julie R. Nangia, Robyn T. Burns, Jennifer Savoie, Antonio C. Wolff, Eric P. Winer, Mothaffar F. Rimawi, Ian E. Krop, Nancy U Lin
Ann Oncol.; 2024 Nov; PMID: 38977064

Adjuvant Trastuzumab Emtansine Versus Paclitaxel plus Trastuzumab for Stage I HER2-positive Breast Cancer: 5-year results and correlative analyses from ATEMPT (TBCRC 033)
Paolo Tarantino, MD; Nabihah Tayob, PhD; Guillermo Villacampa; Chau Dang, MD; Denise A. Yardley, MD; Steven J. Isakoff, MD, PhD; Vicente Valero, MD; Meredith Faggen, MD; Therese Mulvey, MD; Ron Bose, MD, PhD; Douglas Weckstein, MD; Antonio C. Wolff, MD; Katherine Reeder-Hayes, MD, MBA, MSc; Hope S. Rugo, MD; Bhuvaneswari Ramaswamy, MD; Dan Zuckerman, MD; Lowell Hart, MD; Vijayakrishna K. Gadi, MD, PhD; Michael Constantine, MD; Kit Cheng, MD; Audrey Merrill Garrett, MD; P. Kelly Marcom, MD; Kathy Albain, MD; Patricia DeFusco, MD; Nadine Tung, MD; Blair Ardman, MD; Rita Nanda, MD; Rachel C. Jankowitz, MD; Mothaffar Rimawi, MD; Vandana Abramson, MD; Paula R. Pohlmann, MD, PhD, MSc; Catherine Van Poznak, MD; Andres Forero-Torres, MD; Minetta Liu, MD; Kathryn J. Ruddy, MD; Yue Zheng, MSc; Romualdo Barroso-Sousa, MD, PhD; Adrienne G. Waks, MD; Michelle DeMeo, BS; Molly DiLullo, BS; Giuseppe Curigliano, MD, PhD; Harold J. Burstein, MD, PhD; Ann H. Partridge, MD, MPH1,2; Giuseppe Viale, MD3,34; Patrizia Dell'Orto34; Leila Russo34; Emma Krause PhD; Christian Kirkup; Winnie Hui, PhD; Daniel J. Newhouse; Busem Binboğa Kurt, Elizabeth A. Mittendorf, MD, PhD; MD; Bryan Schneider, MD; Aleix Prat, MD, PhD; Eric P. Winer, MD; Ian E. Krop, MD, PhD; and Sara M. Tolaney, MD, MPH
J Clin Oncol.; 2024 Nov; PMID: 38935923

Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome (TBCRC 038)
Siri H. Strand, Kathleen E. Houlahan, Vernal Branch, Thomas Lynch, Bryan Harmon, Fergus Couch, Kristalyn Gallagher, Mark Kilgore, Shi Wei, Angela DeMichele, Tari King, Priscilla McAuliffe, Christina Curtis, Kouros Owzar, Jeffrey R. Marks, Graham A. Colditz, E. Shelley Hwang, Robert B. West
Breast Cancer Res.; 2024 Sep 2; PMID: 39223670

TBCRC 039: a phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer
Filipa Lynce, Laura E. Stevens, Zheqi Li, Jane E. Brock, Anushree Gulvady, Ying Huang, Faina Nakhlis, Ashka Patel, Jeremy M. Force, Tufia C. Haddad, Naoto Ueno, Vered Stearns, Antonio C. Wolff, Amy S. Clark, Jennifer R. Bellon, Edward T. Richardson, Justin M. Balko, Ian E. Krop, Eric P. Winer, Paulina Lange, E. Shelley Hwang, Tari A. King , Sara M. Tolaney, Alastair Thompson, Gaorav P. Gupta, Elizabeth A. Mittendorf, Meredith M. Regan, Beth Overmoyer, Kornelia Polyak
Breast Cancer Res., 2024 Jan 31; PMID: 38297352

Atezolizumab in Combination With Carboplatin and Survival Outcomes in Patients With Metastatic Triple-Negative Breast Cancer: The TBCRC 043 Phase 2 Randomized Clinical Trial
Brian D. Lehmann, Vandana G. Abramson, Elizabeth C. Dees, Payal Shah, Tarah J. Ballinger, Claudine Isaacs, Cesar A. Santa-Maria, Hanbing An, Paula I. Gonzalez-Ericsson, Melinda E. Sanders, Kimberly N. Newsom, Richard G. Abramson, Quanhu Sheng, Chih-Yuan Hsu, Yu Shyr, Antonio C. Wolff, and Jennifer A. Pietenpol
JAMA Oncol.; 2024 Feb 1; PMID: 38095878

NKG2A Is a Therapeutic Vulnerability in Immunotherapy Resistant MHC-I Heterogeneous Triple-Negative Breast Cancer [TBCRC 043]
Brandie C Taylor, Xiaopeng Sun, Paula I Gonzalez-Ericsson, Violeta Sanchez, Melinda E Sanders, Elizabeth C Wescott, Susan R Opalenik, Ann Hanna, Shu-Ting Chou, Luc Van Kaer, Henry Gomez, Claudine Isaacs, Tarah J Ballinger, Cesar A Santa-Maria, Payal D Shah, Elizabeth C Dees, Brian D Lehmann, Vandana G Abramson, Jennifer A Pietenpol, Justin M Balko
Cancer Discov.; 2024 Feb 8; PMID: 37791898

Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer [TBCRC 043]
Elizabeth C Wescott, Xiaopeng Sun, Paula Gonzalez-Ericsson, Ann Hanna, Brandie C Taylor, Violeta Sanchez, Juliana Bronzini, Susan R Opalenik, Melinda E Sanders, Julia Wulfkuhle, Rosa I Gallagher, Henry Gomez, Claudine Isaacs, Vijaya Bharti, John T Wilson, Tarah J Ballinger, Cesar A Santa-Maria, Payal D Shah, Elizabeth C Dees, Brian D Lehmann, Vandana G Abramson, Gillian L Hirst, Lamorna Brown Swigart, Laura J van ˈt Veer, Laura J Esserman, Emanuel F Petricoin, Jennifer A Pietenpol, Justin M Balko
Cancer Res Commun.; 2024 Apr 24; PMID: 38687247

TBCRC 057: Survey About Willingness to Participate in Cancer Clinical Trials During the Pandemic
Karen L. Smith, Carolyn Mead-Harvey, Gina L. Mazza, Eileen H. Shinn, Elizabeth S. Frank, Michelle E.  Melisko, Cyd Eaton, Yisi Liu,Jeannine M. Salamone, Terri Pollastro, Patricia A. Spears, Nicole E. Caston, Antonio C. Wolff, Gabrielle B. Rocque
Cancer Med.; 2024 Mar; PMID: 38466037